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1

Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold

Liu, Jian, Peng, Xia, Dai, Yang, Zhang, Wei, Ren, Sumei, Ai, Jing, Geng, Meiyu, Li, Yingxia

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

2

Molecularly targeted cancer therapy: some lessons from the past decade

Huang, Min, Shen, Aijun, Ding, Jian, Geng, Meiyu

Journal:

Trends in Pharmacological Sciences

Year:

2014

Language:

english

File:

PDF, 825 KB

english, 2014

3

Synthesis and structure–activity relationship study of pyrazolo[3,4- d ]pyrimidines as tyrosine kinase RET inhibitors

Wang, Chengyan, Liu, Hongchun, Song, Zilan, Ji, Yinchun, Xing, Li, Peng, Xia, Wang, Xisheng, Ai, Jing, Geng, Meiyu, Zhang, Ao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 963 KB

english, 2017

4

Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration - Erratum

Zhang, Dadong, Wu, Heming, Zhang, Xiaomin, Ding, Xu, Huang, Min, Geng, Meiyu, Li, Hongwei, Xie, Zuoquan

Journal:

Journal of Cancer

Year:

2020

Language:

english

File:

PDF, 625 KB

english, 2020

5

Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors

Liu, Zhiqing, Yue, Xihua, Song, Zilan, Peng, Xia, Guo, Junfeng, Ji, Yinchun, Cheng, Zhen, Ding, Jian, Ai, Jing, Geng, Meiyu, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

6

Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases

Song, Zilan, Yang, Yanhong, Liu, Zhiqing, Peng, Xia, Guo, Junfeng, Yang, Xinying, Wu, Kui, Ai, Jing, Ding, Jian, Geng, Meiyu, Zhang, Ao

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

7

Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation

Geng, Kaijun, Xia, Zongjun, Ji, Yinchun, Zhang, Ruisi (Ruthy), Sun, Deqiao, Ai, Jing, Song, Zilan, Geng, Meiyu, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 822 KB

english, 2017

8

Novel Conjugates of Aspirin with Phenolic Acid as Anti-inflammatory Agents Having Significantly Reduced Gastrointestinal Toxicity

Shan Jiang, Ning Ding, Wei Zhang, Yichun Zhang, Meiyu Geng, Yingxia Li

Journal:

Archiv der Pharmazie

Year:

2010

Language:

english

File:

PDF, 574 KB

english, 2010

9

Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

Li, Xiaoguang, Tang, Shuai, Wang, Qian-Qian, Leung, Elaine L.-H., Jin, Hongyue, Huang, Yongzhuo, Liu, Jia, Geng, Meiyu, Huang, Min, Yuan, Shengtao, Yao, Xiao-Jun, Ding, Jian

Journal:

Frontiers in Pharmacology

Year:

2017

Language:

english

File:

PDF, 2.77 MB

english, 2017

10

Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2- a ]pyridine Derivatives as Potent c-Met Inhibitors

Li, Chunpu, Ai, Jing, Zhang, Dengyou, Peng, Xia, Chen, Xi, Gao, Zhiwei, Su, Yi, Zhu, Wei, Ji, Yinchun, Chen, Xiaoyan, Geng, Meiyu, Liu, Hong

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 309 KB

english, 2015

11

Preclinical evaluation of SCC244 (Glumetinib), a novel, potent and highly selective inhibitor of c-Met in MET-dependent cancer models

Ai, Jing, Chen, Yi, Peng, Xia, Ji, Yinchun, Xi, Yong, Shen, Yanyan, Yang, Xinying, Su, Yi, Sun, Yi-Ming, Gao, Yinglei, Ma, Yuchi, Xiong, Bing, Shen, Jingkang, Ding, Jian, Geng, Meiyu

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 13.72 MB

english, 2017

12

Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities

Liu, Zhiqing, Ai, Jing, Peng, Xia, Song, Zilan, Wu, Kui, Zhang, Jing, Yao, Qizheng, Chen, Yi, Ji, Yinchun, Yang, Yanhong, Geng, Meiyu, Zhang, Ao

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 731 KB

english, 2014

13

Synthesis and Evaluation of Novel Non-Covalent Binding Quinazoline Glycoside Derivatives Targeting the L858R and T790M variants of EGFR

Zhang, Ren-Shuai, Chen, Shaopeng, Zhang, Xiaowei, Yu, Rilei, Wan, Shengbiao, Geng, Meiyu, Jiang, Tao

Journal:

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

14

Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models

Peng, Xia, Hou, Pengcong, Chen, Yi, Dai, Yang, Ji, Yinchun, Shen, Yanyan, Su, Yi, Liu, Bo, Wang, Yueliang, Sun, Deqiao, Jiang, Yuchen, Zha, Chuantao, Xie, Zuoquan, Ding, Jian, Geng, Meiyu, Ai, Jing

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 6.33 MB

english, 2019

15

Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs

Geng, Kaijun, Liu, Hongchun, Song, Zilan, Zhang, Chi, Zhang, Minmin, Yang, Hong, Cao, Jingchen, Geng, Meiyu, Shen, Aijun, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 871 KB

english, 2018

16

N-acetylglucosaminyltransferase V Modifies TrKA Protein, Regulates the Receptor Function

Xiaoyun Yang, Jing Li, Meiyu Geng

Journal:

Cellular and Molecular Neurobiology

Year:

2008

Language:

english

File:

PDF, 268 KB

english, 2008

17

N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway

Yunxue Zhao, Jing Li, Yanli Xing, Jingjian Wang, Congxiao Lu, Xianliang Xin, Meiyu Geng

Journal:

Molecular and Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 565 KB

english, 2008

18

T-cell receptor (TCR)/CD3 is involved in sulfated polymannuroguluronate (SPMG)-induced T lymphocyte activation

Benchun Miao, Jing Li, Xueyan Fu, Jian Ding, Meiyu Geng

Journal:

International Immunopharmacology

Year:

2005

Language:

english

File:

PDF, 380 KB

english, 2005

19

Back Cover: Discovery of 3H-Imidazo[4,5-b]pyridines as Potent c-Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation (ChemMedChem 6/2012)

Dr. Danqi Chen, Ying Wang, Yuchi Ma, Dr. Bing Xiong, Dr. Jing Ai, Prof. Yi Chen, Prof. Dr. Meiyu Geng, Prof. Dr. Jingkang Shen

Journal:

Year:

2012

File:

PDF, 1.43 MB

2012

20

Acidic Oligosaccharide Sugar Chain, a Marine-Derived Acidic Oligosaccharide, Inhibits the Cytotoxicity and Aggregation of Amyloid Beta Protein

Hu, Jinfeng, Geng, Meiyu, Li, Jing, Xin, Xianliang, Wang, Jia, Tang, Minke, Zhang, Juntian, Zhang, Xiao, Ding, Jian

Journal:

Journal of Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 451 KB

english, 2004

21

Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors

Zheng, Qiangang, tang, Shuai, Fu, Xianlei, Chen, Ziqi, Ye, Yan, Lan, Xiaojing, Jiang, Lei, Huang, Ying, Ding, Jian, Geng, Meiyu, Huang, Min, Wan, Huixin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 347 KB

english, 2017

22

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors

Liu, Ruiqi, Zhang, Zhuqing, Yang, Hong, Zhou, Kaixin, Geng, Meiyu, Zhou, Weicheng, Zhang, Mingming, Huang, Xun, Li, Yingxia

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.34 MB

english, 2019

23

Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes

Benchun Miao, Meiyu Geng, Jing Li, Fuchuan Li, Haixia Chen, Huashi Guan, Jian Ding

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 411 KB

english, 2004

24

Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway

Liang, Zhongjie, Ai, Jing, Ding, Xiao, Peng, Xia, Zhang, Dengyou, Zhang, Ruihan, Wang, Ying, Liu, Fang, Zheng, Mingyue, Jiang, Hualiang, Liu, Hong, Geng, Meiyu, Luo, Cheng

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.74 MB

english, 2013

25

Discovery of novel type II c-Met inhibitors based on BMS-777607

Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

26

Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization

An, Xiao-De, Liu, Hongyan, Xu, Zhong-Liang, Jin, Yi, Peng, Xia, Yao, Ying-Ming, Geng, Meiyu, Long, Ya-Qiu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.77 MB

english, 2015

27

Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors

Xiao, Xuanzheng, Lai, Mengzhen, Song, Zilan, Ding, Jian, Geng, Meiyu, Xie, Hua, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.96 MB

2020

28

Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects

Dr. Lin Du, Dr. Jing Ai, Dr. Dehai Li, Dr. Tianjiao Zhu, Dr. Ying Wang, Michael Knauer, Dr. Torsten Bruhn, Dr. Hongbing Liu, Dr. Meiyu Geng, Prof. Dr. Qianqun Gu, Prof. Dr. Gerhard Bringmann

Journal:

Chemistry - A European Journal

Year:

2011

Language:

english

File:

PDF, 400 KB

english, 2011

29

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold

Ailing Zhao, Xin Gao, Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Meiyu Geng, Ao Zhang

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.60 MB

english, 2011

30

Design, synthesis, and structure–activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists

Ma, Haikuo, Lu, Wenfeng, Sun, Zhijian, Luo, Lusong, Geng, Delong, Yang, Zhaohui, Li, Enqin, Zheng, Jiyue, Wang, Meiyu, Zhang, Hongjian, Yang, Shilin, Zhang, Xiaohu

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

31

Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90

Meng, Tao, Zhang, Dadong, Xie, Zuoquan, Yu, Ting, Wu, Shuchao, Wyder, Lorenza, Regenass, Urs, Hilpert, Kurt, Huang, Min, Geng, Meiyu, Shen, Jingkang

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.90 MB

english, 2014

32

Design and Optimization of a Series of 1-Sulfonylpyrazolo[4,3- b ]pyridines as Selective c-Met Inhibitors

Ma, Yuchi, Sun, Guangqiang, Chen, Danqi, Peng, Xia, Chen, Yue-Lei, Su, Yi, Ji, Yinchun, Liang, Jin, Wang, Xin, Chen, Lin, Ding, Jian, Xiong, Bing, Ai, Jing, Geng, Meiyu, Shen, Jingkang

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.74 MB

english, 2015

33

Design, Synthesis and Biological Evaluation of c-Met kinase inhibitors bearing 2-oxo-1, 2-dihydroquinoline Scaffold

Cui, Hong, Peng, Xia, Liu, Jian, Ma, Chunhua, Ji, Yinchun, Zhang, Wei, Geng, Meiyu, Li, Yingxia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 548 KB

english, 2016

34

Alzheimer’s disease hypothesis and related therapies

Du, Xiaoguang, Wang, Xinyi, Geng, Meiyu

Journal:

Translational Neurodegeneration

Year:

2018

Language:

english

File:

PDF, 398 KB

english, 2018

35

Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients

Zhu, Jiang, Wu, Yu-Nong, Zhang, Wei, Zhang, Xiao-Min, Ding, Xu, Li, Huai-Qi, Geng, Meiyu, Xie, Zuo-Quan, Wu, He-Ming, Tang, Chih-Hsin

Journal:

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

36

[ACM Press the 27th ACM International Conference - Nice, France (2019.10.21-2019.10.25)] Proceedings of the 27th ACM International Conference on Multimedia - MM '19 - Fine-grained Cross-media Representation Learning with Deep Quantization Attention Network

Liang, Meiyu, Du, Junping, Liu, Wu, Xue, Zhe, Geng, Yue, Yang, Congxian

Year:

2019

File:

PDF, 2.05 MB

2019

37

Glucose Transporter 1, Distribution in the Brain and in Neural Disorders: Its Relationship With Transport of Neuroactive Drugs Through the Blood-Brain Barrier

Guo Xiuli, Geng Meiyu, Du Guanhua

Journal:

Biochemical Genetics

Year:

2005

Language:

english

File:

PDF, 96 KB

english, 2005

38

Identification of AOSC-binding proteins in neurons

Ming Liu, Qin Nie, Xianliang Xin, Meiyu Geng

Journal:

Chinese Journal of Oceanology and Limnology

Year:

2008

Language:

english

File:

PDF, 681 KB

english, 2008

39

Discovery of 4-chloro-3-(5-(pyridin-3-yl)-1,2,4-oxadiazole-3-yl)benzamides as novel RET kinase inhibitors

Han, Mei, Li, Shan, Ai, Jing, Sheng, Rong, Hu, Yongzhou, Hu, Youhong, Geng, Meiyu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 888 KB

english, 2016

40

Corrigendum to “Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core” [Bioorg. Med. Chem. Lett. 26 (2016) 5399–5402]

Han, Mei, Wang, Chengyan, Ji, Yinchun, Song, Zilan, Xing, Li, Su, Yi, Wang, Xisheng, Zhang, Ao, Ai, Jing, Geng, Meiyu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 411 KB

2020

41

Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

Zhang, Chi, Wang, Xin, Liu, Hongchun, Zhang, Minmin, Geng, Meiyu, Sun, Liping, Shen, Aijun, Zhang, Ao

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

42

Total Synthesis of (±)-Tanshinol B, Tanshinone I, (±)-Tanshindiol B and C

Wang, Fan, Yang, Hong, Yu, Shujuan, Xue, Yu, Fan, Zhoulong, Liang, Gaolin, Geng, Meiyu, Zhang, Ao, Ding, Chunyong

Journal:

Organic & Biomolecular Chemistry

Year:

2018

Language:

english

File:

PDF, 719 KB

english, 2018

43

Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-κB via targeting of Mre11

Jing Zhang, Xianliang Xin, Qin Chen, Zuoquan Xie, Min Gui, Yi Chen, Liping Lin, Jianming Feng, Qiuning Li, Jian Ding, Meiyu Geng

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

44

Design and Synthesis of a Series of Novel Bisquinazoline Glycosides as Epidermal Growth Factor Receptor Inhibitors

Shaopeng Chen, Xiaowei Zhang, Junlei Wang, Shengbiao Wan, Meiyu Geng, Tao Jiang

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 287 KB

english, 2011

45

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors

Wang, Yuanxiang, Ai, Jing, Liu, Gang, Geng, Meiyu, Zhang, Ao

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 280 KB

english, 2011

46

Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a Novel Anticancer Agent

Wang, Yuanxiang, Ai, Jing, Wang, Ying, Chen, Yi, Wang, Lu, Liu, Gang, Geng, Meiyu, Zhang, Ao

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

47

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Ren, Jing, Li, Jian, Wang, Yueqin, Chen, Wuyan, Shen, Aijun, Liu, Hongchun, Chen, Danqi, Cao, Danyan, Li, Yanlian, Zhang, Naixia, Xu, Yechun, Geng, Meiyu, He, Jianhua, Xiong, Bing, Shen, Jingkang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.38 MB

english, 2014

48

Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold

Jiang, Xiaolong, Liu, Hongyan, Song, Zilan, Peng, Xia, Ji, Yinchun, Yao, Qizheng, Geng, Meiyu, Ai, Jing, Zhang, Ao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 676 KB

english, 2015

49

Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors

Liu, Dr Yang, Peng, Xia, Guan, Xiaocong, Lu, Dong, Xi, Yong, Jin, Shiyu, Chen, Hui, Zeng, Limin, Ai, Jing, Geng, Meiyu, Hu, Youhong

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

50

Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives

Lu, Dong, Yan, Juan, Wang, Lang, Liu, Hongchun, Zeng, Limin, Zhang, Minmin, Duan, Wenwen, Ji, Yinchun, Cao, Jingchen, Geng, Meiyu, Shen, Aijun, Hu, Youhong

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

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